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    Nov 06, 2015

    Tapeworm that spread tumours to man stuns experts


    STUNNED scientists described on Wednesday the first known case of a man infected with tumours by a common parasitic tapeworm, raising concerns about more such infections that may go undetected.

    "We were amazed when we found this new type of disease - tapeworms growing inside a person essentially getting cancer that spreads to the person, causing tumours," said Atis Muehlenbachs, staff pathologist in the United States Centres for Disease Control and Prevention's (CDC's) Infectious Diseases Pathology Branch.

    "We think this type of event is rare. However, this tapeworm is found worldwide and millions of people globally suffer from conditions like HIV that weaken their immune system. So there may be more cases that are unrecognised," added Dr Muehlenbachs, lead author of the study in the New England Journal of Medicine.

    The case involved a 41-year-old man in Colombia. He was HIV-positive and had not been taking medications when in 2013, he went to his doctors with a cough, fever and complaints of weakness and weight loss.

    They took biopsies from his lymph nodes and lung tumours and appealed to the CDC for help in diagnosing some bizarre-looking lesions which looked like human cancer, but initial lab tests showed they were not human.

    "The growth pattern was decidedly cancer-like, with too many cells crowded into small spaces and quickly multiplying," the CDC said in a statement.

    "But the cells were tiny - about 10 times smaller than a normal human cancer cell. The researchers also noticed cells fusing together, which is rare for human cells."

    After dozens of tests, they found DNA from Hymenolepis nana (H. nana), the dwarf tapeworm, in the man's tumour in mid-2013.

    The man died soon after.

    The dwarf tapeworm is the most common tapeworm in humans and infects up to 75 million people at any given time.

    People can get it by eating food that has mouse faeces on it or ingesting faeces from an infected person. Many people show no symptoms.

    "However, in people whose immune systems are weak, including people who have HIV or are taking steroids, the tapeworm thrives," the CDC said.

    H. nana is the only one of some 3,000 known tapeworms that can complete its entire life cycle from egg to adult tapeworm in an individual's small intestine.

    Rarely are infections of the tapeworm found outside the small intestine, but in the case of the Colombian man, his weakened immune state may have enabled the parasite's cancer to spread through his body.